Nektar Therapeutics to Regain Full Rights to Rezpegaldesleukin

Nektar Therapeutics to Regain Full Rights to Rezpegaldesleukin

Nektar Therapeutics (Nasdaq: NASDAQ: NKTR ) today announced that it will be regaining the full rights to REZPEG from Eli Lilly and Company.

As announced in a press release issued on April 17, Nektar plans to move forward with REZPEG and will initiate a Phase 2b study in patients with moderate-to-severe atopic dermatitis in 2023. The company will also explore other auto-immune indications for the development plan for REZPEG.

Phase 1b data for REZPEG in atopic dermatitis were presented at an investment presentation made by Eli Lilly and Company in December 2021 and at the 2022 European Academy of Dermatology (EADV). REZPEG evidenced a dose-dependent improvement over placebo for key efficacy measures of mean change in EASI, EASI-75, vIGA-AD scores, and Itch NRS ≥4-point scales. These improvements were observed for an additional 36 weeks following the 12-week treatment period.

"The promising Phase 1b data presented at the 2022 EADV conference warrant moving REZPEG forward into Phase 2 development," said Jonathan Silverberg, MD, PhD, MPH, Associate Professor of Dermatology at The George Washington University School of Medicine and Health Sciences in Washington, DC and the Director of Clinical Research and Contact Dermatitis. "The durability of the response may offer an opportunity for a quarterly maintenance dosing regimen and improved long-term disease control."

The proof-of-concept data presented to-date on REZPEG also evidenced REZPEG's ability to stimulate Tregs to target an immune system imbalance resulting in an improvement of disease activity in patients. In addition, REZPEG data were recently highlighted in a talk by Eric Lawrence Simpson, MD, FAAD at the 2023 American Academy of Dermatology (AAD) Annual Meeting on March 17, 2023 in the scientific session covering atopic dermatitis, as a potential future remittive therapy.

"We are pleased to be regaining full rights to REZPEG," said Howard W. Robin, President and CEO of Nektar. "We plan to work quickly to initiate a Phase 2b study in atopic dermatitis. We believe the strong data generated to-date for REZPEG in atopic dermatitis show the significant potential for REZPEG to emerge as an innovative new mechanism with the possibility of disease resolution in a growing biologic treatment field. We are excited about REZPEG's immune-modulatory profile and believe it could offer great hope in the future to patients who are managing this common and debilitating condition. We look forward to demonstrating this in the clinic as quickly as possible."

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