* FTSE 100 down 0.1 pct; FTSE 250 up 0.1 pct
* Fuller Smith & Turner, Earthport surge on M&A news
* Vodafone hit June 2010 lows after Q3 report
* Miners hit 3-week high (Adds company news item, analyst comment, closing prices)
By Muvija M and Shashwat Awasthi
Jan 25 (Reuters) - British share indexes posted their first weekly losses of 2019 with the main bourse closing in the red for a fourth straight day, as Vodafone tumbled and a stronger pound weighed on exporter stocks.
The blue-chip index shed 2.3 percent this week, its biggest loss in seven weeks. The mid-cap index had its worst week since Dec. 21, dropping 0.6 percent.
Sterling rallied to an 11-week high on growing optimism that Britain will avoid a no-deal Brexit after a newspaper report that Northern Ireland's Democratic Unionist Party has privately decided to back May's Brexit deal next week if it includes a time limit to the Irish backstop.
However, the European Union has consistently said it won't put an end date on the backstop.
Stocks with greater international exposure were among the biggest drags on the main index on accelerating dollar weakness, as AstraZeneca AZN.L , GSK GSK.L and British American Tobacco (JO: SNHJ ) BATS.L all fell.
Oil majors .FTNMX0530 erased gains and closed lower despite crude prices rising as turmoil in Venezuela renewed concerns that its exports could be disrupted. O/R
Miners .FTNMX1770 outperformed the main index and climbed to three-week highs as copper and gold rose. Fresnillo FRES.L surged 6.1 percent on its best day in more than three months and Antofagasta ANTO.L , Glencore GLEN.L and Anglo American AAL.L all advanced.
Brexit headlines still drove moves although nothing significant has transpired since British Prime Minister Theresa May's Brexit proposed agreement fell through.
"It's not immediately apparent we are any further forward. However, markets still appear to be pricing in the prospect that something will be agreed to avoid a no-deal Brexit," said Michael Hewson, chief market analyst at CMC Markets UK.
Vodafone VOD.L slid 5 percent, extending Thursday's loss, after it said its key revenue measure deteriorated in the third quarter. The stock is down over 10 percent this year, underperforming the wider index, which is up 1.4 percent.
"South Africa was a hit yesterday. They're still trying to reacquire growth lost from the sale of Verizon (NYSE: VZ ) Wireless in the States, which was a cash cow. There's no guarantee that acquisitions will work and they are expensive," said Accendo Markets analyst Mike van Dulken.
A.G. Barr BAG.L , the maker of popular Scottish soft drink Irn-Bru, fell 4.5 percent on the mid-caps index as it flagged prolonged economic uncertainty in Britain and regulatory intervention in the soft drinks industry. .FTSC outperformed with a 0.5 percent gain. Pub chain Fuller, Smith & Turner FSTA.L surged 15.5 percent to its best day on record after agreeing to sell its beer business to a unit of Japan's Asahi 2502.T .
Shares in AIM-listed Earthport EPO.L added nearly a third in value after U.S.-based Mastercard (NYSE: MA ) MA.N topped rival Visa (NYSE: V ) V.N with a 33 pence per share buyout offer. Its shares rose 31.3 percent to their highest in over three years.
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